Monday, November 30, 2009

Hydrotropy biodata Maheshwari R K

BIODATA  (15-9-09)

PERSONAL DETAILS

 

 

¨         Name             -         Dr. Rajesh Kumar Maheshwari

¨         Nationality     -         Indian

¨         Date of Birth  -         9th August 1958

¨         Title                -        Professor

¨         Marital status  -         Married

 

PROFESSIONAL CONTACT DETAILS

 

 

 

¨         Mailing Address  -       G.S. Institute of Pharmaceutical Sciences,

23, Park Road,

Indore-452003 (M.P.)

 

¨         Email ID             -        rkrkmaheshwari@yahoo.co.in

ACADEMIC RECORDS

 

 

 

             

S.No.

Examination

Year

Univ/ Board

Marks

Division

Remarks

1

Higher Secondary

1975

Board of secondary Education M.P.Board, Bhopal

77.5%

First

 

2.

B.Pharm.

1979

Dr. H.S.Gour University,

Sagar (MP)

70.6%

First

Second in Merit List

3.

M.Pharm.

Specialization in Pharmaceutics

1981

Dr. H.S.Gour University,

Sagar (MP)

67.9%

First

‘Gold Medalist’

4.

Ph.D

2008

School of Pharmacy, DAVV, Indore (MP)

 

 

 

 

HONOURS AND AWARDS

 

 

 

¨         Secured a certificate of merit from ministry of education and society welfare, Govt. of India on the basis of High Position in Higher Secondary Examination (1975).

¨         M.Pharm. “Gold Medalist” (1981).

¨         Recipient of Junior Research Fellowship from UGC during M.Pharm (1980-1981).

¨         Recipient of Senior Research Fellowship from UGC during (Oct.1985-Feb.1988).

¨         Awarded a mini research project on “Formulation and evaluation of fast release products of Carbamazepine and Ibuprofen” by MPCOST, Bhopal.

¨         Awarded the “Indian Drug Manufacturers’ Association Research Award”,2005 in the discipline of Pharmaceutical Analysis.

¨          

 

TEACHING EXPERIENCE

¨         Post Graduation Classes- 18 Years.

¨         Under Graduation Classes- 20Years.

 

INDUSTRIAL EXPERIENCE

 

 

¨         Served M/s Martand Pharmaceuticals,Baraut (U.P.)  as manufacturing chemist for 2 years and 8 months(12th Jan 1983 to 27th Sep 1985) and got approvals as manufacturing chemist for injectables, liquids(oral), tablets ,capsules and ointments.

 

PREVIOUS PROFESSIONAL ADMINISTRATIVE TASKS

 

 

¨         Worked as “ In-charge of Pharmaceutics” at S.C.S.College of Pharmacy, Harapanahalli (Karnataka) (21.9.81 to 11.11.82)

¨         Member ,Board of Studies for Pharmaceutical Sciences, Faculty of Technology, Devi Ahilya Vishwavidhyala, Indore

¨         Member, Board of Studies, RGPV, Bhopal (2003)

EXTRA CURRICULAR ACTIVITIES

 

 

 

¨         Junior Diploma in YOGA-     Dr. H.S. Gour University, Sagar(1976)

 

AFFILIATIONS

             

 

 

¨         Life Member of Indian Society for Technical Education, New Delhi.

¨         Life Member of Association of Pharmacy Teachers of India, Banglore.

¨         Life Member of Indian Pharmaceutical Association.

 

RESEARCH PROFILE

 

 

 

¨         Research Expertise

o  Taste Masking

o  Solubility enhancement (hydrophobic solubilization)

o  Dissolution rate enhancement (solid dispersions)

o  Fast disintegration (dispersible tablets)

o  Gastroretentive mucoadhesive drug delivery

o  Optimization of sustained release matrix tablets

o  Mouth dissolving tablets

o  Novel application of hydrotropy in the analysis of poorly water-soluble drugs.

o  Novel application of hydrotropy in the preparation of solid dispersions of poorly water-soluble drugs.

o  Novel application of hydrotropy in the formulation of syrup dosage form of poorly water-soluble drugs to enhance bioavailability.

o  Novel application of hydrotropy in the formulation of topical dosage form of poorly water-soluble drugs with enhanced permeation.

o  Novel application of mixed-hydrotropy in the formulation of syrup dosage form of poorly water-soluble drugs to enhance bioavailability.

o  Novel application of mixed-hydrotropy in the formulation of injection dosage form.

o  Novel application of mixed-solvency in the analysis of poorly water-soluble drugs.

o  Novel application of mixed-solvency in the formlation of solid dispersions, of poorly water-soluble drugs to enhance bioavailability.

o  Novel application of mixed-solvency in the formulation of syrup dosage form of poorly water-soluble drugs to enhance bioavailability.

o  Novel application of mixed-solvency in the formulation of injection dosage form.

 

 

 

SYMPOSIUM/WORKSHOPS

 

 

¨         Attended one week summer school on ‘ Biopharmaceutics and modern analytical techniques organized by department of pharmacy, S.G.S.I.T.S., Indore from 6th to 12th June, 1988.

¨         Attended Lab Manual Workshop at Department of Pharmacy, SGSITS, Indore from 29th to 30th March, 1990.

¨         Attended National Symposium on novel and controlled drug delivery systems in the Department of Pharmaceutical Sciences, Dr.H.S.Gour University, Sagar (MP) from 25th to 27th Feb, 1991.

¨         Participated in the National Symposium on ‘ Recent Advances in Drug Design’ at Department of Pharmacy, SGSITS, Indore under the auspices of the Madhya Pradesh Council Sciences & Technology, Bhopal from 21st to 23rd March, 1992.

¨         Participated in the winter school on ‘Modern Trends in Computer Based Automation’ organized at SGSITS,Indore fron 3rd to 14th Jan,1994.

¨         Participated in the winter school sponsored by Indian Society for Technical Education on ‘Combustion Generated Pollution’ held Dec 13 to Dec. 24, 1994 in the faculty of Engg. & Technology, Jamia Milia Islamia, New Delhi-110025.

¨         Attended refresher course in Chemistry conducted by academic staff college, Devi Ahilya Vishwavidhyalya, Indore from 6th to 25th Feb. 1995.

¨         Participated in the AICTE-ISTE short term training programme conducted by the Deptt. Of applied chemistry, SGSITS, Indore on ‘Waste Utilization: Emerging Technology and Business Opportunity’ from 14th to 26th Dec, 1999.

¨         Attended the ‘ Teaching Methodology’ programme organized by SGSITS,Indore from 4th to 8th Feb, 2002. The programme was conducted by Technical Teacher’s Training Institute, Bhopal.

¨         Participated in the AICITE sponsored ISTE short term training programme on ‘Advances in CAD/CAM/CAE’ by Deptt. Of Production Engg. At SGSITS, Indore from 1st to 12th July, 2002.

 

UG PROJECTS GUIDED

 

 

S.No.

Project Title

Name of Student

Year

1.

Prodrug approach and utility

Ashok Nair

1995

2.

Ocular controlled release drug delivery systems

Avnish Jain

1995

3.

Transdermal drug delivery systems

Ashish Hemani

1996

4.

Microencapsulation as a dosage form

Manish Mandlia

1997

5.

Drug therapy in tuberculosis

Chetan Anand Chourasia

1998

6.

Tuberculosis disease, its prevention and cure

Ravindran Aiyer

1999

7.

Microencapsulation Techniques

Arvind Raikwar

1999

8.

Important drying techniques used in pharmaceutical practice

Arvind Lal Masih

1999

9.

A review on treatment of diabetes

Prashant Agrawal

2000

10.

Liposomal drug delivery systems

Narendra Singh Panwar

2001

11.

A review on polymer coating of Microencapsulation

Seema Kapasiya

2001

12.

Customized Pharmaceutical Care

Vikash Jain

2002

13.

An introduction to Novel Drug Delivery System

Prashi Jain

2002

 

M.PHARM.PROJECTS GUIDED

             

 

 

S.No.

Project Title

Name of Student

Year

1.

HPLC assay validation of 80/574, a hypolipidemic drug, in rat serum and its applications to Log P determination and oral pharmacokinetics

Anekant Jain

2001

2.

Hydrotropic solubilization and aqueous injection formulation studies of Ofloxacin

S.Paswan

2001

3.

Studies on Rofecoxib solid dispersions

Rakesh Sharma

2002

4.

Formulation and evaluation of aqueous injection of Carvedilol

T.Ramesh

2002

5.

Formulation and evaluation of dispersible tablets

U.S.Bagul

2002

6.

Studies on Celecoxib solid dispersions

Gopal Krishna Murthy

2002

7.

Hydrotropic solubilization and aqueous injection formulation studies of Norfloxacin

Rashmi Dahima

2002

8.

Formulation and evaluation of parenteral dosage form of Chlorthalidone

Rama Bharat

2003

9.

Development of software and optimization of sustained release matrix tablets of Diltiazem Hydrochloride

Ramakant Panda

2003

10.

Hydrotropic solubilization studies for aqueous injection formulation and evaluation of Spironolactone

Mrs. Archana Mehrotra

2003

11.

Formulation & evaluation of gastro retentive mucoadhesive drug delivery system(controlled release matrix tablets) of Diltiazem Hydrochloride

Raja Mohamed S

2003

12.

Software development and optimization of sustained release chlorpheniramine maleate tablets

Masheer Ahmed Khan

2003

13.

Taste masking of Fexofenadine Hydrochloride and development of its mouth dissolving dosage form-

Mona Nagar

2003

14.

Formulation and evaluation of transparent topical Clindamycin Phosphate gel and Gentamycin Sulphate gel

Venu Gopal S

2004

15.

Formulation development of sustained release matrix tablets of Stavudine

Manu Tripathi

2004

16.

Formulation and release kinetic studies of controlled release tablets of Propranolol Hydrochloride

L.Sambath

2004

17.

              Formulation and development of hydrophilic matrix based oral controlled drug delivery system of Metformin Hydrochloride

Manoj Bari

2004

18.

Application of hydrotropy in the spectrophotometric estimation of some drugs in solid dosage forms

Aseem Tewari

2004

19.

Taste Masking of Sildenafil Citrate and development of its dispersible tablet dosage form

Gyanda Shankar Dash

2004

20.

Formulation and development of mouth dissolving tablet of Granisetron hydrochloride

J.Kausalya

2005

21.

Enhancement of dissolution rate of Aceclofenac by cyclodextrin complexation

Kapil Joshi

2005

22.

Formulation and development of Celecoxib gel and topical permeation enhancement of some poorly soluble drugs

Vineet Dubey

2005

23.

              Development and in-vitro characterization of Aceclofenac agglomerates by novel crystallo-co-agglomeration technique

Alkesh Kumar

2005

24

Design and development of buccal adhesive bilayered tablets for transmucosal delivery of sumatriptan succinate.

R.B. Maheshwari

2006

25

Development and evaluation of carvedilol mouth dissolving tablets using solid dispersion particles.

Pankaj Bhatt

2006

26

Study of some common modified release polymers to provide unique release mechanism.

Madhumita Nayak

2006

27

Formulation,development and evaluation of novel gastro-retentive floating drug delivery systems

Kaustuv Kumar Sahu

2007

28

Tailoring of ketoprofen particle morphology via novel crystallo-co-agglomeration technique to obtain a directly compressible material

Vikash Chavda

2007

29

Formulation and development of mouth dissolving tablets of levoceterizine dihydrochloride

Umesh Ramchandani

2007

30

Novel application of mixed-hydrotropy in formulation development of poorly water-soluble drug

Shraddha Jawade

2008

31

Formulation,development and evaluation of dual release gastroretentive advanced delivery system of furosemide

Yitesh Jagwani

2008

32

Novel application of mixed-hydrotropic solubilization technique in formulation development of poorly water-soluble drug

Arpna Indurkhya

2008

 

ONGOING RESEARCH PROJECTS OF M.PHARM.STUDENTS

             

 

 

¨         Application of mixed-solvency in development of transdermal gel of poorly water-soluble drug.

 

¨         Application of mixed-solvency in the development of controlled release formulations.

 

¨         Application of mixed-solvency in development of fast dissolving oral film  of poorly water-soluble drug.

 

¨         Application of mixed-solvency in development of syrup formulations of poorly water-soluble drugs.

 

 

RESEARCH PUBLICATIONS

 

 

 

A ‘Adsorption studies of Phenformin Hydrochloride on some clays and its application in formulating sustained release dosage forms’ –Indian Journal of Pharm.Sci. 1988, 50(2) pp.101-105, R.K.Maheshwari, S.N.Sharma & N.K.Jain.

Study on some fast release products of Ibuprofen- Indian Drugs, Feb 1989, Vol.26, pp-226-231. G.P.Agrawal, M.M. Molasaria, R.K. Maheshwari & N.K.Jain

1 Analysis of frusemide by application of hydrotropic solubilization phenomenon, R.                 K. Maheshwari , The Indian Pharmacist, Vol. IV, No. 34, April 2005, p. 55-58.

(Details-Titrimetric estimation, Hydrotropic solution- 2 M Sodium benzoate).

2      Spectrophotometric determination of cefixime in tablets by hydrotropic solubilization phenomenon, R. K. Maheshwari , The Indian Pharmacist, Vol. IV, No. 36, June 2005, p. 63-68.

           (Details-Spectrophotometric estimation at 288 nm, Hydrotropic solutions- 8 M                  Urea, 4 M Sodium acetate and 1.25 M Sodium citrate).

3      Application of hydrotropic solubilization phenomenon in spectrophotometric analysis of hydrochlorothiazide tablets, R. K. Maheshwari, S. C. Chaturvedi & N.K. Jain, Indian Drugs, 42(8), August 2005, p. 541-544.

            (Details-Spectrophotometric estimation at 272 and 317nm, Hydrotropic                  solution- 10 M Urea). 

4      Spectrophotometric estimation of drugs using hydrotropic solubilization phenomenon, R. K. Maheshwari & A. Tiwari, The Indian Pharmacist, Vol. IV, No.39, Sept. 2005, p. 79-84.

           (Details-Spectrophotometric estimation of Hydrochlorothiazide and                Indomethacin , Hydrotropic solution- 2 M Sodium benzoate).

5      New application of hydrotropic solubilization in the spectrophotometric estimation of ketoprofen in tablet dosage form, R.K.Maheshwari, The Pharma Review, Vol.3, No. 18, Oct. 2005, p. 123-125.

            (Details-Spectrophotometric estimation at 260 nm, Hydrotropic                  solution- 4 M Sodium aetate). 

6      A novel application of hydrotropic solubilization in the analysis of bulk samples of ketoprofen and salicylic acid, R.K.Maheshwari, Asian J. Chem., Vol. 18, No.1, Jan-March, 2006, p. 393-396.

(Details-Titrimetric estimation, Hydrotropic solutions for Ketoprofen- 2 M Sodium benzoate, 2 M Sodium salicylate and 2 M Sodium acetate, Hydrotropic solutions for Salicylic acid- 2 M Sodium benzoate, 1.25 M Sodium citrate and 8 M Urea). 

7      Novel application of hydrotropic solubilization in the spectrophotometric analysis of tinidazole in dosage form, R.K.Maheshwari, Asian J. Chem., Vol. 18, No.1, Jan-March, 2006, p. 640-644.

                   (Details-Spectrophotometric estimation at 318 nm, Hydrotropic solutions-8 M                  Urea, 4 M Sodium acetate and 1.25 M Sodium citrate).

8      Application of hydrotropy in spectrophotometric determination of pharmaceutical dosage forms, R. K. Maheshwari, S. C. Chaturvedi & N.K. Jain, Indian Drugs, Nov. 2005, Vol. 42, No.11, p. 760-763.IDMA best research award-2005.

                   (Details-Spectrophotometric estimation at 332 nm, Hydrotropic solution-                                2 M Sodium benzoate, Drug Used- Ofloxacin –in --tablets).

9      Simultaneous spectrophotometric estimation of norfloxacin and tinidazole in two component tablet formulations, R.K.Maheshwari, R.B.Maheshwari & P.Bhatt, Asian J. Chem., 2006, Vol. 18, No.2, 2006, p. 1481-1486.

      (Details-Spectrophotometric estimation, Hydrotropic solution- 8 M Urea).

10  Novel application of hydrotropic solubilization in the spectrophotometric analysis of cephalexin in solid dosage form, R.K.Maheshwari, S.P.Pandey, Apeksha Lovlekar, V.Chavda, Arpita Ajmera and H.M.Gupta, Asian J. Chem., 2006, Vol. 18, No.2, 2006, p. 1451-1454.

     (Details-Spectrophotometric estimation at 262 nm, Hydrotropic solution- 8 M               Urea).

11  Application of hydrotropic solubilization in the analysis of aceclofenac,  R.K.Maheshwari, Asian J. Chem., 2006, Vol. 18, No.2,  2006, p. 1572-1574.

(Details-Titrimetric estimation, Hydrotropic solution- 2 M Sodium benzoate).

12  Novel spectrophotometric estimation of some poorly water soluble drugs using hydrotropic solubilizing agents, R. K. Maheshwari, S. C. Chaturvedi & N.K. Jain,, Indian J. Pharm. Sci., March-April, 2006, Vol.68 (2), p.195-198. (Available on google search). http://www.ijpsonline.com/article.asp?issn=0250-474X;year=2006;volume=68;issue=2;spage=195;epage=198;aulast=Maheshwari

              (Details-Spectrophotometric estimation, Hydrotropic solutions- 2 M Sodium               benzoate and 2 M Niacinamide, Drugs used- Metronidazole at 320 nm, Nalidixic               acid at 330 nm, Norfloxacin at 324 nm, Tinidazole at 318 nm).

13  Titrimetric analysis of aceclofenac in tablets using hydrotropic solubilization technique, R. K. Maheshwari, S. C. Chaturvedi & N.K. Jain, Indian Drugs, June 2006, Vol. 43, p. 516-518.

(Details-Titrimetric estimation, Hydrotropic solution- 2 M Sodium benzoate).

14  Spectrophotometric analysis of amoxycillin in tablets using hydrotropic solubilization technique, R.K.Maheshwari, Asian J. Chem., 2006, 18(4), p. 3194-3196.

              (Details-Spectrophotometric estimation at 274 nm, Hydrotropic                  solution- 10 M Urea).

15  Novel application of hydrotropic solubilization in the spectrophotometric analysis of paracetamol tablet dosage form, R.K.Maheshwari, A. Dewangan, P.K.Soni, P.K.Kansagra and S.K.Jain, Asian J. Chem., 2006, 18(4), p. 2879-2882.

              (Details-Spectrophotometric estimation at 245 nm, Hydrotropic                  solution- 10 M Urea).

16  Solid dispersion and syrup formulation of poorly water-soluble drug by hydrotropy, The Indian Pharmacist, Aug. 2006, Vol.V (50), p. 87-90.

              (Drug – Paracetamol, Hydrotropic agent- Urea)

17 Novel application of hydrotropic solubilization in the spectrophotometric analysis of piroxicam in solid dosage form, R.K.Maheshwari Indian Drugs, 43(8), 2006, 683-685.

            (Details-Spectrophotometric estimation at 358 nm, Hydrotropic solution-                                2 M Sodium benzoate).

18  Novel application of hydrotropic solubilizing additives in the estimation of aspirin in bulk sample and tablets, R. K. Maheshwari, S. C. Chaturvedi & N.K. Jain, International J. Pharm. Excip., Vol. 4 (No.3), July-Sept. 2005, p.84-88.

(Details-Titrimetric estimation, Hydrotropic solutions- 2 M Sodium benzoate,

4 M Sodium acetate and 1.25 M Sodium citrate).).

19 A novel application of hydrotropic solubilization in the spectrophotometric estimation of frusemide in tablets, R.K.Maheshwari, The Pharma Review, Oct. 2006, Vol. 4, No. 24, p. 148-149.

              (Details-Spectrophotometric estimation at 330 nm, Hydrotropic solution-                                2 M Sodium benzoate).

20.Quantitative determination of aspirin using hydrotropic solubilization technique, R.K.Maheshwari, S.Kumar, U.Ramchandani, K.Sahoo, C.Khera & S.Varghese, The Indian Pharmacist, 2006, Vol. V, 124-126.

(Details-Titrimetric estimation, Hydrotropic solution- 2 M Niacinamide, Analysis of bulk drug sample and tablets).

21    Application of hydrotropic solubilization phenomenon in spectrophotometric estimation of norfloxacin in tablets, R.K.Maheshwari, Indian Journal of Pharmaceutical Education and Research, Vol. 40 (4 issue no.) 2006, 237-240.

           (Details-Spectrophotometric estimation at 272 nm, Hydrotropic solutions- 8 M                  Urea).

22 Novel application of hydrotropic solubilization in the spectrophotometric analysis of diclofenac sodium in solid dosage form, RKM, V. Chavda, K. Sahoo, S. Varghese, Asian J. Pharmaceutics, Vol. 1 Oct-Dec 2006,30-32.

           (Details-Spectrophotometric estimation at 276 nm, Hydrotropic solutions- 8 M                  Urea).

23.  A novel application of hydrotropic solubilization in the quantitative analysis of bulk sample of ketoprofen and frusemide, R.K.Maheshwari & A. Ajmera, Asian J. Pharmaceutics, Vol. 1, Oct-Dec 2006,  60-62.( Available on google search). http://www.asiapharmaceutics.info/o_a_novel_application.htm

              (Details-Titrimetric estimation, Hydrotropic solution- 0.5 M Ibuprofen sodium).

24.  Novel application of hydrotropic solubilization in the quantitative  analysis of some NSAIDs and their solid dosage forms , R. K. Maheshwari, S. C. Chaturvedi & N.K. Jain, ,, Indian J. Pharm. Sci.,Jan-Feb., 2007, Vol.69 (1), p.101-105.(Available on google search). http://www.ijpsonline.com/article.asp?issn=0250-474X;year=2007;volume=69;issue=1;spage=101;epage=106;aulast=Maheshwari

              (Details-Titrimetric estimation, Hydrotropic solution- 2 M Sodium benzoate, Drugs estimated- Ibuprofen, Flurbiprofen and Naproxen).

25 A novel application of hydrotropic solubilization in the spectrophotometric analysis of  gatifloxacin in solid dosage form , R.K.Maheshwari, H.M.Gupta, M.Singh, U.Ramchandani & S.P.Pandey, Asian J. Chem., 2008, Vol. 20, No. 1, 241-244.

           (Details-Spectrophotometric estimation at 333 nm, Hydrotropic solution- 2 M               Sod.Benz. and 1.5 M               Metformin hydrochloride. NOTE- Metformin               hydrochloride is an inexpensive antidiabetic drug – about rupees 150/ Kg ).

26.Analysis of frusemide by application of hydrotropic solubilization phenomenon in solid dosage form,  R.K.Maheshwari, S.P.Pandey,  H.M.Gupta, U. Ramchandani & H.M.Gupta, Asian J. Chem., Asian J. Chem., 2008, Vol. 20, No. 1, 277-281.

              (Details-Titrimetric estimation of bulk drug sample and tablets, Hydrotropic solution- 2 M Sodium salicylate).

27.Analysis of amoxicillin by application of hydrotropic solubilization phenomenon in solid dosage form, R.K.Maheshwari, S.Deswal, D.Tiwari, N.Ali & S.Jain,  Asian J. Chem., Asian J. Chem., Asian J. Chem., 2008, Vol. 20, No. 1, 805-807.              (Details-Spectrophotometric estimation at 274 nm, Hydrotropic solution- 5 M                  Potassium acetate).

28 Hydrotropic solubilization in spectrophotometric analysis of cefixime in solid dosage form, R.K.Maheshwari, Nidhi Dubey, Nitin Dubey & Maheveer Singh, Asian J. Chem., Asian J. Chem., Asian J. Chem., 2008, Vol. 20, No. 1, 375-379.              (Details-Spectrophotometric estimation at 288 nm, Hydrotropic solution- 8 M                  Potassium acetate and 6 M Ammonium acetate).

29   A pplication of hydrotropic solubilization technique for quantitative determination of aspirin, , R.K.Maheshwari and R. Awasthi, Asian J. Chem., Asian J. Chem., Asian J. Chem., Asian J. Chem., 2008, Vol. 20, No. 1, 814-816.

              (Details-Titrimetric estimation of aspirin tablets, Hydrotropic solution- 10 M Urea).

30.Novel spectrophotometric estimation of frusemide using hydrotropic solubilization phenomenon, R.K.Maheshwari, S.Deswal, D.Tiwari, N.Ali, B. Pothen & S.Jain, Indian J. Pharm. Sci., 2007,69,Issue 6, 822-24.

(Details-Titrimetric estimation, Hydrotropic solution- 0.5 M Ibuprofen sodium    NOTE- Ibuprofen sodium is an economic drug).

31. Application of hydrotropic solubilization phenomenon in  spectrophotometric determination of cefixime in tablets,R.K.Maheshwari,Dilshad Arif,Priyanka Mittal, Arpana Indurkhya, Shradha Jawade and Pooja Manchandani, Indian Drugs, 2007,44,Nov 2007, 870-73.

                  (Details-Spectrophotometric estimation at 288 nm, Hydrotropic solution- 0.5 M                  Potassium citrate).

     32    Mixed hydrotropy in spectrophotometric analysis of aceclofenac,                                           R.K.Maheshwari, The Indian Pharmacist, 2007, Vol.VI, No.64, 67-69.

              (Details-Spectrophotometric estimation at 274 nm, Hydrotropic solution-                             Mixture of 22.5%w/v urea and 22.5% w/v sodium citrate, Drug used-               Aceclofenac.

33   Novel method of analysis for ibuprofen and flurbiprofen bulk drugs using               ibuprofen sodium solution as hydrotropic solubilizing agent, RKMaheshwari,               Chanpreet Khera and Apeksha Lovlekar, The Pharma Review, Vol.5,  Dec. 2007,               p. 167-169.

              (Details-Titrimetric estimation, Hydrotropic solution- 0.5 M ibuprofen sodium solution).

 

              http://www.google.co.in/search?source=ig&hl=en&rlz=1G1GGLQ_ENIN248&q              =hydrotropy++analysis&btnG=Google+Search&meta=

 

34   Quantitative determination of ketoprofen bulk drug using sodium salt of aspirin as hydrotropic solubilizing agent, RKMaheshwari and Mahaveer Singh, Asian Journal of Chemistry, Vol.20, No. 6, 2008, 4922-24.

              (Details-Titrimetric estimation, Hydrotropic solution- 1.0 M  Aspirin Sodium).

 

35   Quantitative spectrophotometric estimation of famotidine  hydrotropic solubilization technique, RKMaheshwari and Ravi Shankar Shukla, Asian Journal of Chemistry, Vol.20, No. 6, 2008, 4221-24.

              (Details-Spectrophotometric estimation at 286 nm, Hydrotropic solution- 1.5               M   Metformin HCl).

36   Quantitative estimation of naproxen in bulk sample and tablet formulation using niacinamide as hydrotropic solubilizing agent, RKMaheshwari and Anshuman Dubey, Asian Journal of Chemistry, Vol.20 No. 6, 2008, 4225-28.

(Details-Titrimetric estimation, Hydrotropic solution- 2.0 M Niacinamide solution).

37   Analysis of ketoprofen by application of hydrotropic solubilization technique, RKMaheshwari and S. Kumar, The Indian Pharmacist, March 2008, Vol.7, 69-70.

(Details-Titrimetric estimation,  Hydrotropic solution- 2.0 M Potassium Acetate and 0.5 M Potassium Citrate solution).

38   Novel method for spectrophotometric analysis of hydrochlorothiazide tablets using niacinamide as hydrotropic solubilizing agent, R.K.Maheshwari, Ravi Shankar Shukla, Asian J. Pharmaceutics, Vol. 2, 2008, 68-69.

       (Details-Spectrophotometric estimation  at 317nm, Hydrotropic                  solution- 2 M                 Niacinamide). 

39   Tailoring of ketoprofen particle morphology via novel crystalloagglomeration technique to obtain a directly compressible material, Vikash Chavda, R.K.Maheshwari,  Asian J. Pharmaceutics, Vol. 2, 2008, 61-67.

40   Spectrophotometric analysis of cefixime trihydrate tablets using metformin hydrochloride as hydrotropic solubilizing agent, R.K.Maheshwari, M. Kinariwala, M. Saxena, M. Gahlot, R. Chaki, Y. Jagwani, Asian J. Chem., 2008, 20(8), p. 6047-6050.

           (Details-Spectrophotometric estimation at 288 nm, Hydrotropic solutions- 0.5 M                  Metformin Hydrochloride).

41   Spectrophotometric analysis of hydrochlorothiazide tablets using chlorpheniramine maleate as hydrotropic solubilizing agent, R.K.Maheshwari, S. R. Bisnoi, D. Kumar, Asian J. Chem., 2008, 20(8), p. 6594-6596.

       (Details-Spectrophotometric estimation  at 317nm, Hydrotropic                  solution- 20 %                   Chlorpheniramine  Maleate). 

42   Quantitative analysis of hydrochlorothiazide tablets using lignocaine hydrochloride as hydrotropic agent,  R.K.Maheshwari, S. Deswal, D. Tiwari, N. Ali,  S. Jain, Asian J. Chem., 2009, 21(2), p. 1642-1644.

       (Details-Spectrophotometric estimation at 317nm, Hydrotropic                  solution- 1 M                 Lignocaine hydrochloride). 

43   A novel method for quantitative determination of aceclofenac in bulk drug and tablets using ibuprofen sodium as a hydrotropic solubilizing agent, R.K.Maheshwari, D. Arif, P.Mittal, P. Manchandani, A. Indurkhya, S. Jawade, Journal of Applied Chemical and Research, 2008, 5, 63-68.

      (Details-Titrimetric estimation, Hydrotropic solution- 0.5 M ibuprofen sodium).

44   Simultaneous spectrophotometric estimation of metronidazole and norfloxacin in combined tablet formulations using hydrotropy, Deepika Maliwal, Anurekha Jain, R.K. Maheshwari, Vidyasagar Patidar, Research Journal of Pharmacy and Technology, 2008, Vol.1. 357-361. (Details- Spectrophotometric, 8M urea solution)

45   Analysis of bulk sample of salicylic acid by application of hydrotropic solubilization method, R.K. Maheshwari, V. Chavada, S. Varghese and K. Sahoo, Indian J. Pharm. Sci., 2008, 70, 823-825. (Details- Titrimetric, 0.5 M ibuprofen sodium solution, 2M sodium salicylate solution.)

46   Spectrophotometric estimation of naproxen tablets employing sodium benzoate as hydrotropic additives, R.K.Maheshwari, A. Indurkhya, S. Jawade, Y. Jagwani. The Indian Pharmacist., 2009, VIII, 75-77. (Details- Spectrophotometric estimation at 331 nm, 2 M sodium benzoate)

47   Estimation of ibuprofen in bulk and tablets using ibuprofen sodium as hydrotropic solubilizing agent, R. K. Maheshwari, S.R. Bishnoi, D.Kumar, N.V.Murlikrishna. Asian J Chem., 2009, 21, 5897-5900. (Details- Titrimetric estimation using 0.5 M ibuprofen sodium solution.)

48   Quantitative estimation of aspirin using hydrotropic solubilization technique, R. K. Maheshwari, R. Aher, G. Wanare, Y. Jagwani, A. Kapoor, A. Joshi, A. Khandelwal. Asian J Chem., 2009, 21, 6590-6592. (Details- Titrimetric estimation using 2 M sodium salicylate solution.)

49   Solubilization of ibuprofen by mixed solvency approach, R. K. Maheshwari, The Indian Pharmacist, 2009, VIII, 81-84. (Details- Titrimetric estimation using blends containing various solubilizers.)

50   Quatitative estimation of naproxen in tablets using ibuprofen sodium as hydrotropic agent. R. K. Maheshwari, G. Wanare, N. Chahar, P. Joshi, N. Nayak, Indian J. Pharm. Sci., 2009, 71, 335-337. (Details- Spectrophotometric estimation at 331 nm, 0.5 M ibuprofen sodium solution.)

             

 

 

 

 

PAPERS PRESENTED IN CONFERENCES – by-22-10-09

 

1.    Analysis of bulk sample of salicylic acid by application of hydrotropic solubilization method,  R.K. Maheshwari, Vikash Chavda, Kaustuv Sahu, Shiju Varghese  (58th IPC, Mumbai).

2.    A novel application of hydrotropic solubilization in the spectrophotometric analysis of gatifloxacin in solid dosage form, R.K. Maheshwari, H.M. Gupta, M. Singh, U. Ramchandani, S.P. Pandey (58th IPC, Mumbai).

  1. Application of hydrotropic solubilization phenomenon in the spectrophotometric analysis of cefixime tablets, R.K. Maheshwari, N. Dubey, Nitin Dubey, Pankaj Pandey, Mahaveer Singh (58th IPC, Mumbai).
  2. Optimization of chlorpheniramine maleate sustained release matrix tablets, Masheer Ahmad Khan, R. K. Maheshwari , (59th IPC, Varanasi).

5.    Novel application of hydrotropic solubilization in the preparation of solid dispersion  of poorly water soluble drugs, R. K. Maheshwari, S. C. Chaturvedi, N. K. Jain(59th  IPC,   Varanasi).

  1. Novel application of hydrotropic solubilization in the preparation of syrup (liquid  oral  solution) of  poorly water soluble drugs, R. K. Maheshwari, S. C. Chaturvedi, N. K. Jain, (59th IPC, Varanasi).
  2. Taste masking of fexofenadine hydrochlorthiazide and development of its mouth dissolving dosage form, Nager Mona, R. K. Maheshwari, Roy S. B., Ramchandani U., (59th IPC,  Varanasi).
  3. New spectrophotometric estimation of method for gatifloxacin using ibuprofen sodium as hydrotropic solubilizing additive”, R. K. Maheshwari, Arpna Indurkhya, Shraddha Jawade, Yitesh Jagwani, (59th IPC, Varanasi).

9.    New spectrophotometric estimation of naproxen tablets employing  sodium  benzoate as hydrotropic additive, R. K. Maheshwari, Arpna Indurkhya, Shraddha Jawade, Yitesh Jagwani, (59th IPC, Varanasi).

  1. New spectrophotometric estimation of tinidazole tablet using ibuprofen sodium as hydrotropic solubilizing agent, R. K. Maheshwari, Anshu Joshi, Ankita kapoor, Priyamvda Sharma, (59th IPC, Varanasi).
  2. Novel application of hydrotropic solubilization phenomenon in spectrophotometric determination of atenolol in its tablets, R. K. Maheshwari, S. C. Chaturvedi, N. K. Jain,  (59th IPC, Varanasi).
  3. New spectrophotometric estimation of ornidazole tablet using urea as hydrotropic solubilizing agent, R. K. Maheshwari, R. P. Prajapat, V. K. Srivastava, S. R. Bishnoi.
  4. New spectrophotometric estimation of ornidazole tablet using sodium benzoate as hydrotropic solubilizing agent, R. K. Maheshwari, Naveen Chaklan, Vikas Saklecha, Virendra Singh Yadav, Amit Kumar Solanki, R. Rajgopalan
  5. New analytical method to estimate salicylic acid in the bulk drug sample using hydrotropy,R. K. Maheshwari, A. K. Solanki, V. S. Yadav, (59th IPC, Varanasi).
  6. New spectrophotometric determination of naproxen tablets using niacinamide as hydrotropic solubilizing agent”, R. K. Maheshwari, Rajesh Sharma, (59th IPC,  Varanasi).

16.                     Application of hydrotropic solubilization phenomenon in spectrophotometric analysis of hydrochlorthiazide tablets, R. K. Maheshwari, Ravi Shanker  Shulka,(59th IPC,  Varanasi).

  1. Novel application of hydrotropic solubilization in the preparation of solid dispersion of poorly water soluble drugs, R. K. Maheshwari, S. C. Chaturvedi, N. K. Jain, (12th APTI Annual National Convention, Chandigarh).
  2. Development and in vitro characterization of aceclofenac agglomerates by novel crystallo-co-agglomeration technique, A. Kumar, V. Chavda, K. Sahoo, R. K. Maheshwari, (12th APTI Annual National Convention, Chandigarh).
  3. Quantitative analysis of salicylic acid using sodium tartrate as hydrotropic solubilizing agent, APTI 2008, R. K. Maheshwari, N. Chaklan, R. Rajagopalan, APTI(13th) 2008.
  4. Quantitative analysis of cefixime tablets employing calcium disodium edetateas hydrotropic solubilizing additive, R. K. Maheshwari, R. Rajagopalan, N. Chaklan, APTI(13th), 2008.
  5. Furosimide analysis; “ A new era of hydrotropic analysis”, R. K. Maheshwari, Y Jagwani, APTI(13th) 2008.
  6. “A novel method of quantitative spectrophotometric determination of nalidixic acid tablet formulation using ibfrofensodium as hydrotropic solubilizing agent”, R. K. Maheshwari, A.S. Baghel, K. Agnihotri, S.K.Singh,VKSrivastava, D.Kumar and S.R.Bisnoi, APTI(13th), 2008.
  7. “Quantitative estimation of naproxen in tablets using Ibuprofen Sodium as hydrotropic agent” , R. K. Maheshwari, Nishi Nayak, Prajakta Joshi, Gajanan Wanare, Nitika Chahar, APTI(13th), 2008.
  8. Eco friendly method to estimate ibuprofen in bulk drug using Ibuprofen Sodium as hydrotropic solubilizing agent, R. K. Maheshwari, S.R.Bisnoi, D kumar, A Khandelwal, K. Agnihotri, R.P. Prajapat, M.K. Akula, APTI(13th), 2008.
  9. Eco friendly method to esdtimate ibuprofen in tablets using ibuprofen sodium as hydrotropic solubilizing agent, R. K. Maheshwari, S.R.Bisnoi, D kumar,S.K. Singh, A.S. Baghel, V.K.Srivastava, APTI(13th), 2008.
  10. Novel application of mixed hydrotropy  spectrophotometric analysis of poorly water soluble drug, R. K. Maheshwari, Shradha Jawade, APTI(13th), 2008.
  11. A novel method for quantitative determination of aceclofenac I bulk and tablets using ibuprofen sodium as hydrotropic solubilizing agent, R. K. Maheshwari, D.Arif, P. Mital, P. Manchadani, A, Indurkhya, S. Jawade, APTI(13th), 2008.
  12. Novel application of hydrotropic solubilizing additives in estimation of aspirin in tablets” , R. K. Maheshwari, M.Galhot, M. Saxena, M. Kinariwala, R. Chaki, APTI(13th), 2008.
  13. “Practical issues of schedule Y ammendment 2005” Y. Jagwani and R. K. Maheshwari, APTI(13th), 2008.
  14. Formulation development of Propranolol hydrochloride as sustained release hydrotropic matrix tablet, R. K. Maheshwari, N,Chaklan, L. Sampath, APTI(13th), 2008.
  15. “Novel  application of  hydrotropic solubilization in the preparation of syrup(Liquid oral solution) of poorly water- soluble drugs”, R. K. Maheshwari, S. C. Chaturvedi,  N. K. Jain, APTI(13th), 2008.
  16. Novel application of mixed hydrotropic solubilization technique in the formulation and evaluation of solid dispersion of Aceclofenac” , R. K. Maheshwari, Arpna Indurkhya, APTI(13th), 2008.
  17. Hydrotropic Solubilization: Novel Pharmaceutical Applications, K.S. Rathore, R.K.Nema, J.S. Dangi and R. K. Maheshwari, , APTI(13th), 2008.
  18. “Ecofriendly spectrophotometric estimation of tinidazole tablets using lidocaine hydrochloride as hydrotropic solubilizing agent”, R. K. Maheshwari, Ritu Chobey, Manoj Moore, Shikhar Verma, IPC(60th) 2008.
  19. “Quantitative spectrophotometric estimation of indomethacin capsules using ibuprofen sodium as hydrotropic solubilizing agent” R.K.Maheshwari, Jain Neha, Behrani Pankaj.
  20. “Quantitative spectrophotometric determination of cefixime tablet formulation using sodium tetraborate as hydrotropic solubilizing agent”,  R.K.Maheshwari, Shruti Moondra , Pankaj Behrani , Aman Agarwal.
  21. “New spectrophotometric estimation of indomethacin capsules with niacinamide as hydrotropic solubilizing agent”, R.K.Maheshwari, Archna Agarwal, Sonali Jayronia, Amit Rathore.
  22. “Ecofriendly spectrophotometric estimation of Atenolol  tablets using metformin HCL as hydrotropic solubilizing agent”,  R.K.Maheshwari, Archna Agarwal, Sonali Jayronia, Amit Rathore.
  23. “Quantitative spectrophotometric estimation of Ketoprofen tablets using sodium citrate as hydrotropic solubilizing agent”,  R.K.Maheshwari, Neha Pandey, Chandan Chandna, Vipul Chauhan.
  24. “New spectrophotometric method to determine Ketoprofen in tablet dosage form using mixed hydrotropy”, R.K.Maheshwari, Archna Agarwal, Sonali Jayronia, Amit Rathore.
  25. “Quantitative spectrophotometric estimation of hydrochlorthiazide tablets using mixed hydrotropy”, R.K.Maheshwari, Ravish Jain, Rajeev Patel, Umesh Atneriya.
  26. “Quantitative spectrophotometric estimation of metronidazole tablets with the help of urea as hydrotropic solubilizing agent”,  R.K.Maheshwari, Vikram Karwande, Ravish Jain, Chandan Chandna.
  27. “Eco-friendly method to determine ibuprofen content in bulk and tablet formulation and using chlorpheniramine maleate as hydrotropic solubilizing agent”,  R.K.Maheshwari, Chandan Chandna Umesh Atneriya Nitin Jaiswal.
  28. “Quantitative estimation of naproxen in bulk and tablet formulation using sodium salicylate as hydrotropic solubilizing agent”,  R.K.Maheshwari, Vipul Chauhan, Ravish Jain, Anek Patil.
  29. “Simple titrimetric estimation of aspirin bulk drug sample using hydrotropic solubilization technique”,  R.K.Maheshwari, Vikram Karwande, Ravish Jain, Umesh Atneriya.
  30. “Quantitative titrimetric estimation of aceclofenac bulk drug and tablets using sodium salicylate as hydrotropic solubilizing agent”,  R.K.Maheshwari, Shruti Moondra.
  31. “Design, development and evaluation of sustained release matrix tablets of stavudine”, Agnihotri K., Tripathi M., Maheshwati R.K.
  32. “Formulation and evaluation of aceclofenac injection made by use of mixed hydrotropic solubilization techniques”, R.K.Maheshwari, Arpana Indurkhya.
  33. “Fast dissolving solid dispersions”- A novel application of mixed hydrotropy ”, R.K.Maheshwari, Yitesh Jagwani.
  34. “Taste masking of sildenafil citrate and development of its dispersible tablet dosage form”, Dash G.S., Rajgopalan R., Chaklan N., Maheshwri R.K.

 

 

 

 

 

DECLARATION

             

 

I hereby declare that the information provided is true to best of my belief.

                                                                                                               

Date-22-10-2009                                                                                                                                                                                                                                                                                          (Dr.R.K.Maheshwari)