NOVEL PHARMACEUTICAL APPLICATIONS OF HYDROTROPIC SOLUBILIZATION IN PHARMACY

It is my keen desire to give some interesting message regarding the
NOVEL PHARMACEUTICAL APPLICATIONS OF HYDROTROPIC SOLUBILIZATION IN VARIOUS FIELDS OF PHARMACY
to as many scientists/researchers as possible. For this, I have collected e-mail ID of all of you from your published papers in various journals. My aim is to spread the applications of hydrotropy to develop eco-friendly and economic methods in analysis and formulation fields. Please go through some examples given in the form of attached files.

What is HYDROTROPIC SOLUBILIZATION---?????

Hydrotropy is a solubilization phenomenon whereby addition of large amount of a second solute results in an increase in the aqueous solubility of another solute. Concentrated aqueous hydrotropic solutions of sodium benzoate, sodium salicylate, urea, nicotinamide, sodium citrate and sodium acetate have been observed to enhance the aqueous solubilities of many poorly water-soluble drugs. Aqueous injection of caffeine with sodium benzoate (a hydrotropic agent) is a classical example. For further details please see the matter on hydrotropy (in the attached files).

NOVEL PHARMACEUTICAL APPLICATIONS OF HYDROTROPIC SOLUBILIZATION IN VARIOUS FIELDS OF PHARMACY

1 Quantitative estimations of poorly water-soluble drugs by uv-visible spectrophotometric analysis precluding the use of organic solvents.

2 Quantitative estimations of poorly water-soluble drugs by titrimetric analysis precluding the use of organic solvents.


3 Preparation of hydrotropic solid dispersions of poorly water-soluble drugs precluding the use of organic solvents.

4 Preparation of ready to use syrups of poorly water-soluble drugs.

5 Preparation of dry syrups (for reconstitution) of poorly water-soluble drugs.

6 Preparation of topical solutions of poorly water-soluble drugs.

7 The use of hydrotropic solubilizers as permeation enhancers.

8 The use of hydrotropy to give fast release of poorly water-soluble drugs from the suppositories.

9 Application of mixed- hydrotropy to develope injection dosage forms of poorly water-soluble drugs.

10 Application of hydrotropic solubilization in nanotechnology (by controlled precipitation).


11 Application of hydrotropic solubilization in extraction of active constituents from crude drugs (in pharmacognosy field).

12 I have tried the application of hydrotropy in TLC also (for poorly water- soluble drugs) and there is definite scope of hydrotropy in the field of TLC and HPTLC in future to develop eco-friendly mobile phases minimizing/ precluding the use of organic solvents. ( At present I do not have any published paper in this field).

13 Hydrotropic solutions can also be tried to develop the dissolution fluids to carry out the dissolution studies of dosage forms of poorly water-soluble drugs.


NOTE – There is bright future of mixed-hydrotropy in formulations. Hydrotropy is an old concept but it could not be applied in the development of formulations (except injection formulation) due to requirement of large amount of hydrotropic agent. This problem can be solved by mixed-hydrotropy, using the combinations of hydrotropic agents reducing the toxicities of individual hydrotropic agents employed in formulation.


I request you to forward this message to your colleagues etc.
Dr. RAJESH KUMAR MAHESHWARI
PROFESSOR,
Deptt. of Pharmacy,
S.G.S.I.T.S.,
23- Park Road,
Indore-452003 ( M.P.)-INDIA
Ph. No. 09406621907
Res. No. 0731-2542213